A Short Overview Of Quinolones And Flouroquinolones

Quinolones are a type of Synthetic Broad spectrum Antibiotics.They Have Also Been isolated From natural Resources Like Plants,Animals,and Bacteria

Mechanism Of Action :
They Exert Their Anti Bacterial Action By Preventing Bacterial DNA from Duplicating and Unwinding .

Drugs In This Class : Nalidix Acid

This is The Parent Compound Of All Other Drugs in This Group. This Drug were introduced In 1962. When This Drug (Nalidix Acid) Get Flourinated This Drug is Then Called Flouroqiunolones.Typicaly Flourine atom Get attach To the 6 Position or C7 position Of the Central Ring .

Uses:Uncomplicated Urinary Tract Infection

Generations

First Generation : Nalidix Acid
(Only Achieve Minimum Serum Concentration)

Second Generation: CiproFloxacin,Ofloxacin
(Effective against Gram negative Bacteria)
Uses:Complicated Urinary Tract Infection
         Pyelonephritus
Third Generation:Levofloxacin,Moxifloxacin,Gatifloxacin,Sparfloxacin,Levaquin
(Effective against Gram positive and atypical Pathogens)

Uses: Community Acquired Pneumonia
                       Acute Bacterial Sinusitus
Adverse Events:Although Quinolones Are Safe and well Tolerated But certain Adverse Events Are Common in this Group Of Antibiotics These are;
 ●GIT :Nausea,Vomiting,Diarhea,Abdominal Pain
 ●CNS:Headache,Vertigo,Dissines,Drowsiness,Confusion,Insomnia,Depression,Lightheadedness,Tremer,Restlesness etc
 ●Dermatologic:Skin Rashes,Pruritus

 ●Others : Hepatotoxicity,Tendon Rupture,Bitter Taste